Serum Matrix Metalloproteinase 7 Is a Diagnostic Biomarker of Biliary Injury and Fibrosis in Pediatric Autoimmune Liver Disease

Serum MMP7 was evaluated as a biomarker for sclerosing cholangitis in paediatric patients with autoimmune liver disease (AILD). Higher sMMP7 levels associated with histologic bile duct injury and hepatic fibrosis, and on MRCP+ correlated with the number of biliary dilatations and strictures, supporting sMMP7 as a noninvasive indicator of ductal disease severity.