Reply to: Reassessing the causal relationship between liver diseases and cardiovascular outcomes and to: From Liver to Heart: Enhancing the Understanding of Cardiovascular Outcomes in the UK Biobank

This opinion piece states that MASLD is an obesity-related condition that requires both imaging- and genetic-risk tools for a comprehensive picture of multi-organ associations. Without imaging data, genetic tools such as the Mendelian randomisation method alone may not provide clinically relevant information on liver health and cardiovascular risk in patients with MASLD.