Quantitative liver function imaging and whole genome sequencing – Effective modalities for a new era in personalised decision-making for operable colorectal liver metastases?

In the Precision1 trial, preoperative mpMRI and whole-genome sequencing (WGS) informed personalized surgery for operable colorectal liver metastases. mpMRI frequently influenced surgical plans (e.g., embolization, parenchymal-sparing or more extensive resections, weight management). WGS provided therapeutic and prognostic insights, supporting tailored, multidisciplinary decision-making.