Decreases in cT1 and liver fat content reflect histological improvement induced by therapies in MASH: a multicentre pooled coho rt analysis.

Across three multicentre trials, changes in cT1 and PDFF predicted histologic response to MASH therapy. A reduction in cT1 of -80 ms was associated with a 5-fold increase in the odds of achieving resolution of steatohepatitis, a 30% PDFF reduction had roughly fourfold higher odds, while the optimal threshold of -58% had sevenfold higher odds.